Brooding, moody Art Deco interiors set the sexy tone at this boutique hotel right on the Grand Canal. A private pier welcomes guests arriving by gondola (or motorboat), as does the waterfront bar, serving cocktails in a glamorous vintage setting. The building dates back to the 16th century, and each of the 18 rooms has its own unique layout. Of note among the captivating design features are parquet floors, ornately carved woodwork and elaborate Murano glass mosaics that glimmer brightly along the façade. Further enhancing this tribute to fine living is an enviable location convenient to La Fenice opera house, Palazzo Grassi, the Guggenheim Museum and Piazza San Marco.