Though we love the new hotel brands popping up these days, we're always happy when a Four Seasons comes to town. Along with signature luxury, this one offers a terrific shoreline location in Baltimore's trendy Harbor East neighborhood — making it feel like a destination resort right in the city. Done in handsome shades of brown, guest rooms and suites overlook the harbor and downtown skyline through floor-to-ceiling windows. A nice local touch: abstract artworks from the Washington Color School. The European-style spa features a VIP specialty suite, and the property's highlight is Michael Mina's Wit & Wisdom, A Tavern, offering modern interpretations of classic tavern fare.