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Cafe Sistina Restaurant Review: Cafe Sistina patrons aren’t likely to overlook the dining room's colorful hues mirroring Michelangelo’s frescoes, all painted by owner Sergio Mitrotti himself. The menu is trisected according to The Classics, The Contemporary and The Cutting Edge. This is a restaurant to eat simply, often late at night at the bar. We recommend ordering dishes Mitrotti's grandmother would have made: bruschetta con vongole and linguine alla puttanesca, a spicy marvel full of black olives, capers and anchovies. With a glass of Valpolicella Amarone or Frascati, it's a place to sit back and enjoy the food and the artistic surroundings. A full bar and a reputable wine list round out the experience.